37OA image
Deposition Date 2026-07-29
Release Date 2026-11-04
Last Version Date 2026-11-04
Entry Detail
PDB ID:
37OA
Keywords:
CONTRACTILE PROTEIN
Title:
Cryo-EM structure of human beta-cardiac myosin carrying the E525K mutation in the Interacting-Heads Motif state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Saccharomyces cerevisiae (Taxon ID: 4932)
Aequorea victoria (Taxon ID: 6100)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Mus musculus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.00 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
37OA validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin-7,General control tran
Gene (Uniprot):GCN4, MYH7, GFP
Mutagens:E525K in the myosin-7
Chain IDs:A, B
Chain Length:1315
Number of Molecules:2
Biological Source:Homo sapiens, Saccharomyces cerevisiae, Aequorea victoria
UniProt ID:P12883,P03069,P42212
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin light chain 1/3, skele
Gene (Uniprot):Myl1
Chain IDs:C, D
Chain Length:188
Number of Molecules:2
Biological Source:Mus musculus
UniProt ID:P05977
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin regulatory light chain
Gene (Uniprot):Myl11
Chain IDs:E, F
Chain Length:169
Number of Molecules:2
Biological Source:Mus musculus
UniProt ID:P97457
Ligand Molecules
ADP
MG
PO4
Primary Citation
The dilated cardiomyopathy E525K mutation stabilizes the cardiac myosin interacting-heads motif while activating the isolated motor domain.
Biorxiv ? ? ? (2026)
PMID: 42926450 DOI: 10.64898/2026.10.02.756299
Primary Citation of related structures
37OA
Feedback Form
Name
Email
Institute
Feedback