37LU image
Deposition Date 2026-07-25
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
37LU
Keywords:
MEMBRANE PROTEIN
Title:
NPC1-NPC2 complex with bis-sterol molecule JM046, pH 5.5
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
37LU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:NPC intracellular cholesterol
Gene (Uniprot):NPC1
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O15118 Pfam ID:PF16414, PF22314, PF12349
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:NPC intracellular cholesterol
Gene (Uniprot):NPC2
Chain IDs:B (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P61916 Pfam ID:PF02221
Ligand Molecules
CLR
NAG
Primary Citation
Conformation switch of NPC1 epitomizes a lumen-to-membrane alternating access for nonpolar substrates
To Be Published ? ? ? (?)
Primary Citation of related structures
37LU
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