36XI image
Deposition Date 2026-07-05
Release Date 2026-11-11
Last Version Date 2026-11-11
Entry Detail
PDB ID:
36XI
Keywords:
TRANSPORT PROTEIN
Title:
Cryo-EM structure of SLC6A19-ACE2 complex with Compound 20
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.75 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
36XI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sodium-dependent neutral amin
Gene (Uniprot):SLC6A19
Chain IDs:A, C
Chain Length:603
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q695T7
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Angiotensin-converting enzyme
Gene (Uniprot):ACE2
Chain IDs:B, D
Chain Length:754
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9BYF1 EC:3.4.15.1
Ligand Molecules
A1DLZ
NAG
Primary Citation
Structure-Guided Discovery of Orally Bioavailable Allosteric SLC6A19 Inhibitors that Promote Urinary Amino Acid Excretion In Vivo
J.Med.Chem. ? ? ? (2026)
DOI: 10.1021/acs.jmedchem.6c02154
Primary Citation of related structures
36XI
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