ISDA: 36UJ

Deposition Date 2026-07-01

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

36UJ

Keywords:

OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR

Title:

Crystal Structure of IDH1 (R132H) in complex with covalent inhibitor LY3410738

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.44 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 43 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isocitrate dehydrogenase [NAD
Gene (Uniprot):IDH1
Mutagens:R132H
Chain IDs:A, B
Chain Length:424
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O75874 Pfam ID:PF00180 EC:1.1.1.42

Ligand Molecules

A1DLL

SO4

Primary Citation

LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models

Antonysamy, S.S.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form