36TD image
Deposition Date 2026-06-30
Release Date 2026-07-22
Last Version Date 2026-07-22
Entry Detail
PDB ID:
36TD
Keywords:
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title:
Crystal Structure of IDH2 (R172K) in complex with covalent inhibitor LY3410738
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.00 Å
R-Value Free:
0.24
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
P 21 21 21
36TD validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isocitrate dehydrogenase [NAD
Gene (Uniprot):IDH2
Mutagens:R172K
Chain IDs:A, B
Chain Length:461
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P48735 Pfam ID:PF00180 EC:1.1.1.42
Ligand Molecules
A1DLL
NAP
Primary Citation
LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models
To Be Published ? ? ? (?)
Primary Citation of related structures
36TD
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