ISDA: 36KU

Deposition Date 2026-06-16

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

36KU

Keywords:

SIGNALING PROTEIN

Title:

Tri-complex of Compound 30, KRAS G12D, and CypA

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.24 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:GTPase KRas
Gene (Uniprot):KRAS
Chain IDs:C (auth: A), D (auth: B)
Chain Length:170
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01116 EC:3.6.5.2

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Peptidyl-prolyl cis-trans iso
Gene (Uniprot):PPIA
Chain IDs:A (auth: C), B (auth: D)
Chain Length:166
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62937 EC:5.2.1.8

Ligand Molecules

A1DJ6

GNP

GOL

Primary Citation

Discovery of Zoldonrasib (RMC-9805), a Potent and Orally Bioavailable RAS(ON) G12D-Selective, Covalent, Tri-Complex Inhibitor for the Treatment of Patients with RAS G12D-Addicted Cancers

Burnett, G.L, Weller, C, Jiang, L, Tye, M.A, Tomlinson, A.C.A, Shivakumar, D.M, Xiao, G, Liu, Y, Gliedt, M.J, Edwards, A.V, Aggen, J.B, Lanning, S, Marquez, A, Steele, S.L, Flagella, M, Wang, Z, Singh, M, Wang, Z, Jiang, J, Smith, J.A.M, Wildes, D, Knox, J.E, Koltun, E.S, Gill, A.L.Show

J.Med.Chem. ? ? ? (2026)

DOI: 10.1021/acs.jmedchem.6c02020

Primary Citation of related structures

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