36JS image
Deposition Date 2026-06-14
Release Date 2026-11-11
Last Version Date 2026-11-11
Entry Detail
PDB ID:
36JS
Keywords:
SIGNALING PROTEIN
Title:
Tri-complex of RMC-0708, KRas Q61H, and CypA
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.75 Å
R-Value Free:
0.24
R-Value Work:
0.18
R-Value Observed:
0.19
Space Group:
P 1 2 1
36JS validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Chain IDs:A, B
Chain Length:170
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P01116 EC:3.6.5.2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Peptidyl-prolyl cis-trans iso
Gene (Uniprot):PPIA
Chain IDs:C, D
Chain Length:166
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P62937 EC:5.2.1.8
Ligand Molecules
A1DJS
CL
GNP
GOL
MG
Primary Citation
Discovery of RMC-0708, an Oral, Bis-Macrocyclic, RAS(ON) Q61H-Selective, Noncovalent, Tri-Complex Inhibitor
J.Med.Chem. ? ? ? (2026)
DOI: 10.1021/acs.jmedchem.6c02019
Primary Citation of related structures
36JS
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