ISDA: 36JK

Deposition Date 2026-06-14

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

36JK

Keywords:

BLOOD CLOTTING

Title:

Coagulation factor VIII, full-length, in solution-phase

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Mesocricetus auratus

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.26 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Coagulation factor VIII
Gene (Uniprot):F8
Chain IDs:A
Chain Length:2332
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00451 Pfam ID:PF07732, PF07731, PF00754

Ligand Molecules

CPS

CU1

NAG

Primary Citation

Structural basis for membrane binding by coagulation factors V and VIII and their specificity for phosphatidylserine-containing membranes.

Kolyadko, V.N, Pumroy, R.A, Moiseenkova-Bell, V.Y, Krishnaswamy, S.Show

Proc.Natl.Acad.Sci.USA 123 e2622255123 e2622255123 (2026)

PMID: 42685075 DOI: 10.1073/pnas.2622255123

Primary Citation of related structures

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