ISDA: 36DN

Deposition Date 2026-06-02

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

36DN

Keywords:

VIRAL PROTEIN

Title:

HIV-1 reverse transcriptase (F227C) in complex with DNAddG Aptamer

Biological Source:

Source Organism(s):

Human immunodeficiency virus 1 (Taxon ID: 11676)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Reverse transcriptase/ribonuc
Mutagens:F227C,Q258C,C280S
Chain IDs:A
Chain Length:562
Number of Molecules:1
Biological Source:Human immunodeficiency virus 1

Polymer Type:polypeptide(L)
Molecule:p51 RT
Mutagens:C280S
Chain IDs:B
Chain Length:455
Number of Molecules:1
Biological Source:Human immunodeficiency virus 1

Polymer Type:polydeoxyribonucleotide
Molecule:DNAddG (38-MER)
Chain IDs:C (auth: F)
Chain Length:38
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

DDG

Primary Citation

Allosteric Crosstalk

Hecksel, C.W, Walker, S.N, Raheem, I, Asante-Appiah, E, Calero, G, Diamond, T.L, Gabelli, S.B, Gomez-Llorente, Y, Hayes, R.P, Tummala, S, Vergara, S, Klein, D.J.Show

Acs Infect Dis. ? ? ? (2026)

DOI: 10.1021/acsinfecdis.6c00431

Primary Citation of related structures

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