36BT image
Deposition Date 2026-05-29
Release Date 2026-09-02
Last Version Date 2026-09-23
Entry Detail
PDB ID:
36BT
Keywords:
Title:
HIV-1 reverse transcriptase in complex with DNAddG Aptamer and unincorporated ISL-triphosphate
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
1.85 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Reverse transcriptase/ribonuc
Gene (Uniprot):gag-pol
Mutagens:Q258C,C280S
Chain IDs:A
Chain Length:562
Number of Molecules:1
Biological Source:Human immunodeficiency virus 1
Polymer Type:polypeptide(L)
Molecule:p51 RT
Gene (Uniprot):gag-pol
Mutagens:C280S
Chain IDs:B
Chain Length:455
Number of Molecules:1
Biological Source:Human immunodeficiency virus 1
Polymer Type:polydeoxyribonucleotide
Molecule:DNAddG (38-MER)
Chain IDs:C (auth: F)
Chain Length:38
Number of Molecules:1
Biological Source:synthetic construct
Primary Citation
Allosteric Crosstalk between Inhibitor Binding Sites Drives Enhanced Islatravir Susceptibility in F227C HIV-1 Reverse Transcriptase.
Acs Infect Dis. 12 3179 3190 (2026)
PMID: 42725963 DOI: 10.1021/acsinfecdis.6c00431
Primary Citation of related structures
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