35VB image
Deposition Date 2026-05-19
Release Date 2026-09-23
Last Version Date 2026-09-23
Entry Detail
PDB ID:
35VB
Keywords:
ONCOPROTEIN
Title:
Crystal structure of KRAS G13C (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of BRAF
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.85 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.21
Space Group:
I 4 3 2
35VB validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G13C
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):BRAF
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P15056 Pfam ID:PF02196, PF00130 EC:2.7.10.2
Ligand Molecules
CL
GNP
GOL
MG
ZN
Primary Citation
Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific region
To Be Published ? ? ? (?)
Primary Citation of related structures
35VB
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