ISDA: 35TL

Deposition Date 2026-05-15

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

35TL

Keywords:

DE NOVO PROTEIN

Title:

PD-L1 complexed with Germinal-designed anti-PD-L1 scFv H5

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.93 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Programmed cell death 1 ligan
Gene (Uniprot):CD274
Chain IDs:A
Chain Length:290
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NZQ7 Pfam ID:PF07686, PF08205

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Germinal-designed anti-PD-L1
Chain IDs:B
Chain Length:223
Number of Molecules:1
Biological Source:synthetic construct

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Germinal-designed anti-PD-L1
Chain IDs:C
Chain Length:214
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Efficient generation of epitope-targeted antibodies with Germinal.

Mille-Fragoso, L.S, Driscoll, C.L, Wang, J.N, Dai, H, Widatalla, T, Zhang, J.L, Zhang, X, Rao, B, Feng, L, Hie, B.L, Gao, X.J.Show

Nat.Biotechnol. ? ? ? (2026)

PMID: 42337361 DOI: 10.1038/s41587-026-03187-0

Primary Citation of related structures

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