ISDA: 32WJ

Deposition Date 2026-07-28

Release Date 2026-10-28

Last Version Date 2026-10-28

Entry Detail

PDB ID:

32WJ

Keywords:

LIGASE

Title:

Structure of TRIM8 RING domain in complex with UBE2N~Ub conjugate

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.39 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase T
Gene (Uniprot):TRIM8
Chain IDs:A (auth: I), B (auth: J), G (auth: B), H (auth: C)
Chain Length:83
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q9BZR9 EC:2.3.2.27

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-conjugating enzyme
Gene (Uniprot):UBE2N
Mutagens:C87K, K92A
Chain IDs:C (auth: K), D (auth: L), I (auth: D), J (auth: E)
Chain Length:154
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P61088 EC:2.3.2.23

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin
Gene (Uniprot):UBC
Chain IDs:E (auth: M), F (auth: N), K (auth: F), L (auth: H)
Chain Length:76
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P0CG48

Ligand Molecules

Primary Citation

RING E3 ligase TRIM8 is structurally selective for UBE2N-mediated ubiquitination.

Dudley-Fraser, J, Esposito, D, Rittinger, K.Show

J.Biol.Chem. ? 113642 113642 (2026)

PMID: 42869147 DOI: 10.1016/j.jbc.2026.113642

Primary Citation of related structures

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