32TO image
Deposition Date 2026-07-24
Release Date 2026-09-16
Last Version Date 2026-09-16
Entry Detail
PDB ID:
32TO
Keywords:
ISOMERASE
Title:
T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor IID432
Biological Source:
Source Organism(s):
Trypanosoma cruzi (Taxon ID: 5693)
Escherichia coli (Taxon ID: 562)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.77 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
32TO validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:DNA topoisomerase 2
Chain IDs:A, B
Chain Length:779
Number of Molecules:2
Biological Source:Trypanosoma cruzi
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (16-Mer)
Chain IDs:C, F (auth: J)
Chain Length:16
Number of Molecules:2
Biological Source:Escherichia coli
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (12-Mer)
Chain IDs:D, E (auth: I)
Chain Length:12
Number of Molecules:2
Biological Source:Escherichia coli
Ligand Molecules
A1KFP
MG
Primary Citation
IID432, a parasite-selective topoisomerase II inhibitor, achieves rapid single-dose parasite clearance in a murine chronic Chagas model.
Proc.Natl.Acad.Sci.USA 123 e2620085123 e2620085123 (2026)
PMID: 42715074 DOI: 10.1073/pnas.2620085123
Primary Citation of related structures
32TO
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