ISDA: 32CR

Deposition Date 2026-07-05

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

32CR

Keywords:

PROTEIN BINDING

Title:

SHANK3 PDZ (570-664) in complex with an internal PDZ binding motif (843-864) in Densin-180

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
Rattus norvegicus (Taxon ID: 10116)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.98 Å

R-Value Free:

0.25

R-Value Work:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:SH3 and multiple ankyrin repe
Gene (Uniprot):Shank3
Chain IDs:A, C, E, G
Chain Length:101
Number of Molecules:4
Biological Source:Mus musculus

UniProt ID:Q4ACU6 Pfam ID:PF17820

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat-containin
Gene (Uniprot):Lrrc7
Chain IDs:B, D, F, H
Chain Length:23
Number of Molecules:4
Biological Source:Rattus norvegicus

UniProt ID:P70587

Primary Citation

An internal PDZ-binding motif in Densin-180 promotes activity-dependent SHANK scaffold remodelling

Otani, Y, Srinivasan, V, Toller, J, Kallem, T, Ball, N, Barsukov, I, Saarikangas, J, Kreienkamp, H.J, Goult, B.T.Show

Biorxiv ? ? ? (2026)

DOI: 10.64898/2026.07.07.736929

Primary Citation of related structures

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