31TM image
Deposition Date 2026-06-23
Release Date 2026-10-28
Last Version Date 2026-10-28
Entry Detail
PDB ID:
31TM
Keywords:
LIGASE
Title:
Structure of MKLN1-RANBP9-TWA1 CTLH subcomplex bound to FAM72A C-terminus
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.70 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
31TM validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein FAM72A
Gene (Uniprot):FAM72A
Chain IDs:A
Chain Length:149
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q5TYM5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Muskelin
Gene (Uniprot):MKLN1
Chain IDs:B
Chain Length:735
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UL63
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glucose-induced degradation p
Gene (Uniprot):GID8
Chain IDs:D (auth: E)
Chain Length:266
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NWU2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ran-binding protein 9
Gene (Uniprot):RANBP9
Chain IDs:C (auth: F)
Chain Length:729
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96S59
Ligand Molecules
NA
Primary Citation
Multimodal substrate recruitment enables CTLH MKLN1 E3 ligase to target acetylated N-, C-, and internal degrons.
Nat Commun 17 ? ? (2026)
PMID: 42892655 DOI: 10.1038/s41467-026-78311-4
Primary Citation of related structures
31TM
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