ISDA: 31NP

Deposition Date 2026-06-15

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

31NP

Keywords:

SUGAR BINDING PROTEIN

Title:

Crystal structure of the complex of galectin-8N-2,6-anhydro-3-deoxy-3-S-(beta-D-galactopyranosyl)-3-thio-D-glycero-L-altro-heptonamide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.78 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

I 1 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Galectin-8
Chain IDs:A
Chain Length:317
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1KB4

GOL

YIO

Primary Citation

Structural and Biophysical Characterization of C-Glycosylic 1,2-Thiodisaccharides Reveals Determinants of Selective Binding to Galectin-7 and Galectin-8N.

Tsagkarakou, A.S, Kantsadi, A.L, Theodoridou, V.I, Veliotis, N, Lazar, L, Jozsef, J, Juhasz, L, Kontopidis, G, Leffler, H, Nilsson, U.J, Somsak, L, Leonidas, D.D.Show

Chemmedchem 21 e70439 e70439 (2026)

PMID: 42603778 DOI: 10.1002/cmdc.70439

Primary Citation of related structures

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