ISDA: 31LC

Deposition Date 2026-06-11

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

31LC

Keywords:

FLAVOPROTEIN

Title:

X-ray structure of Thioredoxin reductase (TrxR) from Burkholderia cenocepacia (Bc-TrxR)

Biological Source:

Source Organism(s):

Burkholderia cenocepacia (Taxon ID: 95486)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.52 Å

R-Value Free:

0.36

R-Value Work:

0.25

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Thioredoxin reductase
Chain IDs:A
Chain Length:320
Number of Molecules:1
Biological Source:Burkholderia cenocepacia

UniProt ID:A0A125H2L5

Ligand Molecules

FAD

SO4

Primary Citation

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition.

Zineddu, S, de Azevedo-Franca, J.A, Aguanno, M, Pecchioli, V, Ferraro, G, Cuomo, V, Merlino, A, Messori, L.Show

Chembiochem 27 e70462 e70462 (2026)

PMID: 42427218 DOI: 10.1002/cbic.70462

Primary Citation of related structures

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