ISDA: 31HD

Deposition Date 2026-06-04

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

31HD

Keywords:

LYASE

Title:

Crystal structure of S. aureus HMG-CoA synthase covalently bound to inhibitor

Biological Source:

Source Organism(s):

Staphylococcus aureus (Taxon ID: 1280)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.05 Å

R-Value Free:

0.25

R-Value Work:

0.22

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hydroxymethylglutaryl-CoA syn
Gene (Uniprot):SAUSA300_2484
Chain IDs:A, B, C, D, E, F, G, H
Chain Length:395
Number of Molecules:8
Biological Source:Staphylococcus aureus

UniProt ID:A0A0H2XFD1 EC:2.3.3.10

Ligand Molecules

A1J9W

Primary Citation

A Direct-to-Biology Platform for Rapid Covalent Antibiotic Discovery

van der Voort, S, Gote, T, vant Ooster, S, Gagestein, B, Florea, B.I, van den Berg, R.J.B.H.N, Armstrong, Z, Overkleeft, H.S, Hacker, S.M.Show

Chemrxiv 2026 ? ? (?)

DOI: 10.26434/chemrxiv.15010946/v1

Primary Citation of related structures

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