ISDA: 30TS

Deposition Date 2026-05-13

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

30TS

Keywords:

PEPTIDE BINDING PROTEIN

Title:

14-3-3sigma protein binding to TSC2-weak peptide (AAA mutation) and stabilizer 3'deAc FC-A.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.70 Å

R-Value Free:

0.20

R-Value Work:

0.16

Space Group:

C 2 2 21

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:14-3-3 protein sigma
Chain IDs:A
Chain Length:236
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:TSC2 peptide pS1254 weak muta
Chain IDs:B
Chain Length:10
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

SIT

Primary Citation

Mechanistic Insights into Molecular Glue Cooperativity: A 14-3-3 Case Study

Pennings, M.A.M, Vandenboorn, E.M.F, Nooren, L, Ottmann, C, Brunsveld, L.Show

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Primary Citation of related structures

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