30PU image
Deposition Date 2026-05-07
Release Date 2026-11-04
Last Version Date 2026-11-11
Entry Detail
PDB ID:
30PU
Keywords:
TRANSFERASE
Title:
Structure of a TrkB:BDNF complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Cricetulus griseus
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.00 Å
R-Value Free:
0.28
R-Value Work:
0.25
R-Value Observed:
0.25
Space Group:
C 1 2 1
30PU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:BDNF/NT-3 growth factors rece
Gene (Uniprot):NTRK2
Mutagens:N95Q, N121Q, N178Q, N280Q, N325S
Chain IDs:A, C
Chain Length:392
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q16620 EC:2.7.10.1
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Neurotrophic factor BDNF prec
Gene (Uniprot):BDNF
Chain IDs:B, D
Chain Length:119
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P23560
Ligand Molecules
NAG
Primary Citation
A sulfotyrosine motif in the human TrkB extracellular domain is required for activation by the agonist antibody ZEB85.
Proc.Natl.Acad.Sci.USA 123 e2618780123 e2618780123 (2026)
PMID: 42956030 DOI: 10.1073/pnas.2618780123
Primary Citation of related structures
30PU
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