30PP image
Deposition Date 2026-05-07
Release Date 2026-11-04
Last Version Date 2026-11-11
Entry Detail
PDB ID:
30PP
Keywords:
PROTEIN BINDING
Title:
Structure of a TrkB agonist bound to its TrkB epitope
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.06 Å
R-Value Free:
0.24
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
P 64 2 2
30PP validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:ZEB85
Chain IDs:A, B
Chain Length:248
Number of Molecules:2
Biological Source:synthetic construct
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:BDNF/NT-3 growth factors rece
Gene (Uniprot):NTRK2
Chain IDs:C, D
Chain Length:13
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q16620 EC:2.7.10.1
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
TYS C, D TYR modified residue
Ligand Molecules
CL
EDO
Primary Citation
A sulfotyrosine motif in the human TrkB extracellular domain is required for activation by the agonist antibody ZEB85.
Proc.Natl.Acad.Sci.USA 123 e2618780123 e2618780123 (2026)
PMID: 42956030 DOI: 10.1073/pnas.2618780123
Primary Citation of related structures
30PP
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