ISDA: 30PO

Deposition Date 2026-05-07

Release Date 2026-11-04

Last Version Date 2026-11-11

Entry Detail

PDB ID:

30PO

Keywords:

PROTEIN BINDING

Title:

Apo Structure of a TrkB Agonist

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.88 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 64 2 2

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ZEB85
Chain IDs:A, B
Chain Length:248
Number of Molecules:2
Biological Source:synthetic construct

Ligand Molecules

EPE

GOL

Primary Citation

A sulfotyrosine motif in the human TrkB extracellular domain is required for activation by the agonist antibody ZEB85.

Briggs, D.C, Duffy, R.T, Ateaque, S, Maslen, S, Nagaraj, H, Barde, Y.A, DiStefano, P.S, Lindsay, R.M, Armstrong, P.C, Peach, C.J, McDonald, N.Q.Show

Proc.Natl.Acad.Sci.USA 123 e2618780123 e2618780123 (2026)

PMID: 42956030 DOI: 10.1073/pnas.2618780123

Primary Citation of related structures

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