ISDA: 30JI

Deposition Date 2026-04-29

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

30JI

Keywords:

LIPID TRANSPORT

Title:

Structure of mouse AsterC (GramD1c) with a novel non-steroidal selective inhibitor

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.75 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 41 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein Aster-C
Gene (Uniprot):Gramd1c
Chain IDs:A
Chain Length:173
Number of Molecules:1
Biological Source:Mus musculus

UniProt ID:Q8CI52 Pfam ID:PF16016

Ligand Molecules

A1J6V

EOH

GOL

Primary Citation

Design and structural basis of selective nonsteroidal inhibitors of aster cholesterol trafficking.

Kim, H, Romartinez-Alonso, B, Xiao, X, Gao, Y, Kennelly, J.P, Ferrari, A, Li, R, Cui, L, Whang, E, Schwabe, J.W.R, Jung, M.E, Tontonoz, P.Show

Proc.Natl.Acad.Sci.USA 123 e2617638123 e2617638123 (2026)

PMID: 42679036 DOI: 10.1073/pnas.2617638123

Primary Citation of related structures

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