ISDA: 30GD

Deposition Date 2026-04-23

Release Date 2026-05-13

Last Version Date 2026-07-15

Entry Detail

PDB ID:

30GD

Keywords:

TRANSFERASE

Title:

CryoEM structure of human MATa2 in complex with MAT2B isoform v1 at 2.6 A resolution

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:S-adenosylmethionine synthase
Gene (Uniprot):MAT2A
Chain IDs:C (auth: B), D (auth: A), E (auth: C), F (auth: D)
Chain Length:395
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P31153 Pfam ID:PF00438, PF02772, PF02773 EC:2.5.1.6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Methionine adeno
Gene (Uniprot):MAT2B
Chain IDs:A (auth: E), B (auth: F)
Chain Length:334
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NZL9 Pfam ID:PF04321 EC:2.5.1.6

Ligand Molecules

Primary Citation

CryoEM structures reveal allosteric regulation of the catalytic activity of the multi-protein human MAT enzyme complexes.

Khaja, F.T, Vara, R, Aspinall, L.P, Merriman, C, Maerivoet, A, White, J.B.R, Muench, S.P, Hasnain, S.S, Antonyuk, S.V.Show

Iucrj 13 373 384 (2026)

PMID: 42329745 DOI: 10.1107/S2052252526005075

Primary Citation of related structures

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