2KAW image
Deposition Date 2008-11-17
Release Date 2009-09-15
Last Version Date 2024-05-01
Entry Detail
PDB ID:
2KAW
Title:
NMR structure of the mDvl1 PDZ domain in complex with its inhibitor
Biological Source:
Source Organism(s):
Mus musculus (Taxon ID: 10090)
Expression System(s):
Method Details:
Experimental Method:
Conformers Calculated:
2000
Conformers Submitted:
20
Selection Criteria:
LOWEST ENERGY CONFORMATION
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Segment polarity protein dish
Gene (Uniprot):Dvl1
Chain IDs:A
Chain Length:90
Number of Molecules:1
Biological Source:Mus musculus
Ligand Molecules
Primary Citation
Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.
Angew. Chem. Int. Ed. Engl. 48 6448 6452 (2009)
PMID: 19637179 DOI: 10.1002/anie.200902981
Primary Citation of related structures
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