ISDA: 2BEL

Deposition Date 2004-11-25

Release Date 2004-12-06

Last Version Date 2024-05-01

Entry Detail

PDB ID:

2BEL

Keywords:

OXIDOREDUCTASE

Title:

Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone

Biological Source:

Source Organism(s):

HOMO SAPIENS (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.11 Å

R-Value Free:

0.24

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 21 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:CORTICOSTEROID 11-BETA-DEHYDR
Gene (Uniprot):HSD11B1
Chain IDs:A, B, C, D
Chain Length:283
Number of Molecules:4
Biological Source:HOMO SAPIENS

UniProt ID:P28845 Pfam ID:PF00106 EC:1.1.1.146

Ligand Molecules

CBO

NAP

Primary Citation

The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture

Wu, X, Kavanagh, K, Svensson, S, Elleby, B, Hult, M, von Delft, F, Marsden, B, Jornvall, H, Abrahmsen, L, Oppermann, U.Show

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