ISDA: 29US

Deposition Date 2026-04-09

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

29US

Keywords:

TRANSFERASE

Title:

KAT6A SURFACE MUTANT IN COMPLEX WITH QUINOLINE INHIBITOR COMPOUND-1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.30

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone acetyltransferase KAT
Gene (Uniprot):KAT6A
Mutagens:C638S, C646S, C723S, C773S
Chain IDs:A, B
Chain Length:272
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q92794 Pfam ID:PF17772, PF01853 EC:2.3.1.48

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
ALY	A	LYS	modified residue

Ligand Molecules

A1J4W

Primary Citation

KAT6A-inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches.

Puetter, V, Bouche, L, Nowak-Reppel, K, Ferrara, S.J, Gradl, S.N, Korr, D, Strathdee, C.A, Ter Laak, A, Hillig, R.C.Show

Acta Crystallogr D Struct Biol ? ? ? (2026)

PMID: 42657771 DOI: 10.1107/S2059798326008545

Primary Citation of related structures

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