29UI image
Deposition Date 2026-04-08
Release Date 2026-10-28
Last Version Date 2026-10-28
Entry Detail
PDB ID:
29UI
Keywords:
LIGASE
Title:
FAM72A-UNG2 bound to the discoidin domain of substrate receptor MKLN1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.00 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
29UI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein FAM72A
Gene (Uniprot):FAM72A
Chain IDs:A (auth: B), F (auth: A)
Chain Length:149
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q5TYM5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Uracil-DNA glycosylase
Gene (Uniprot):UNG
Chain IDs:B (auth: D), C
Chain Length:314
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P13051 EC:3.2.2.27
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Muskelin
Gene (Uniprot):MKLN1
Chain IDs:D (auth: F), E
Chain Length:733
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9UL63
Ligand Molecules
ZN
Primary Citation
Multimodal substrate recruitment enables CTLH MKLN1 E3 ligase to target acetylated N-, C-, and internal degrons.
Nat Commun 17 ? ? (2026)
PMID: 42892655 DOI: 10.1038/s41467-026-78311-4
Primary Citation of related structures
29UI
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