29UG image
Deposition Date 2026-04-08
Release Date 2026-10-28
Last Version Date 2026-10-28
Entry Detail
PDB ID:
29UG
Keywords:
LIGASE
Title:
Structure of MKLN1-RANBP9-TWA1 CTLH subcomplex bound to ZMYND19 substrate
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.50 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
29UG validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Muskelin
Gene (Uniprot):MKLN1
Chain IDs:B, F (auth: A)
Chain Length:735
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9UL63
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ran-binding protein 9
Gene (Uniprot):RANBP9
Chain IDs:D (auth: C)
Chain Length:729
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96S59
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glucose-induced degradation p
Gene (Uniprot):GID8
Chain IDs:E (auth: D)
Chain Length:266
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NWU2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Zinc finger MYND domain-conta
Gene (Uniprot):ZMYND19
Chain IDs:A (auth: F), C (auth: E)
Chain Length:227
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q96E35
Ligand Molecules
ZN
Primary Citation
Multimodal substrate recruitment enables CTLH MKLN1 E3 ligase to target acetylated N-, C-, and internal degrons.
Nat Commun 17 ? ? (2026)
PMID: 42892655 DOI: 10.1038/s41467-026-78311-4
Primary Citation of related structures
29UG
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