ISDA: 29UE

Deposition Date 2026-04-08

Release Date 2026-10-28

Last Version Date 2026-10-28

Entry Detail

PDB ID:

29UE

Keywords:

LIGASE

Title:

Focus refined structure of CTLH E3-MKLN1 and substrate-MKLN1 dimer

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.70 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Muskelin
Gene (Uniprot):MKLN1
Chain IDs:A (auth: B), B (auth: A)
Chain Length:735
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UL63

Ligand Molecules

Primary Citation

Multimodal substrate recruitment enables CTLH MKLN1 E3 ligase to target acetylated N-, C-, and internal degrons.

Sepic, S, Gottemukkala, K.V, Du, J, Maiwald, S.A, Chrustowicz, J, Papadopoulou, E.C, Stier, L.J, von Gronau, S, Schulman, B.A.Show

Nat Commun 17 ? ? (2026)

PMID: 42892655 DOI: 10.1038/s41467-026-78311-4

Primary Citation of related structures

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