29TN image
Deposition Date 2026-04-08
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
29TN
Keywords:
TRANSFERASE
Title:
KAT8 MUTANT (KAT6A SURROGATE, MYST-CRYST) IN COMPLEX WITH KAT6A INHIBITOR COMPOUND 38
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.80 Å
R-Value Free:
0.22
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 21 21 21
29TN validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone acetyltransferase KAT
Gene (Uniprot):KAT8
Mutagens:Y95H, A161S, L164M, T165I, K176R, T213S, I216N
Chain IDs:A
Chain Length:278
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H7Z6 Pfam ID:PF17772, PF01853 EC:2.3.1.48
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
ALY A LYS modified residue
Ligand Molecules
A1J4N
CL
GOL
MG
PEG
ZN
Primary Citation
KAT6A-inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches.
Acta Crystallogr D Struct Biol ? ? ? (2026)
PMID: 42657771 DOI: 10.1107/S2059798326008545
Primary Citation of related structures
29TM
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