ISDA: 29PX

Deposition Date 2026-03-27

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

29PX

Keywords:

MEMBRANE PROTEIN

Title:

Crystal structure of the staphylococcal efflux pump QacA in the outward open state bound to ethidium

Biological Source:

Source Organism(s):

Staphylococcus aureus (Taxon ID: 1280)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.79 Å

R-Value Free:

0.35

R-Value Work:

0.32

R-Value Observed:

0.32

Space Group:

P 21 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Antiseptic resistance protein
Gene (Uniprot):qacA
Chain IDs:A, B
Chain Length:520
Number of Molecules:2
Biological Source:Staphylococcus aureus

UniProt ID:P0A0J9

Ligand Molecules

GOL

LMU

OXM

TLA

Primary Citation

Structural and dynamic insights into the staphylococcal efflux pump QacA reveal multidrug transport mechanisms and substrate specificity determinants

Jodaitis, L, Sutton, P, Hutchin, A, Dashtbani-Roozbehani, A, Martens, C, Coppieters, K, Pardon, E, Steyaert, J, O'Mara, M, Brown, M, Govaerts, C.Show

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