ISDA: 29OB

Deposition Date 2026-03-25

Release Date 2026-07-01

Last Version Date 2026-11-04

Entry Detail

PDB ID:

29OB

Keywords:

TRANSCRIPTION

Title:

Crystal structure of RORg LBD in complex with DHEA

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.60 Å

R-Value Free:

0.28

R-Value Work:

0.24

R-Value Observed:

0.25

Space Group:

P 61 2 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nuclear receptor ROR-gamma
Gene (Uniprot):RORC
Chain IDs:A
Chain Length:243
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P51449 Pfam ID:PF00104

Ligand Molecules

AND

Primary Citation

Neurosteroids Inhibit ROR gamma and Induce Major Rearrangement of Its Activation Motif.

Lopez-Garcia, U, Sai, M, Ge, X, Hank, E.C, Wein, T, Marschner, J.A, Morozov, V, Merk, D.Show

Acs Chem.Biol. 21 2216 2223 (2026)

PMID: 42906017 DOI: 10.1021/acschembio.6c00373

Primary Citation of related structures

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