ISDA: 29LN

Deposition Date 2026-03-20

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

29LN

Keywords:

LIGASE

Title:

PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z111782404

Biological Source:

Source Organism(s):

Leishmania major (Taxon ID: 5664)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.33 Å

R-Value Free:

0.29

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

H 3 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-conjugating enzyme
Gene (Uniprot):LMJF_32_0700
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Leishmania major

UniProt ID:Q4Q5L3 Pfam ID:PF00179

Ligand Molecules

IMD

ZTQ

Primary Citation

UbC4 from Leishmania is a Druggable E2 Ubiquitin Conjugating Enzyme: Structural Basis and Fragment Hits for Future E2-Recruiting PROTAC Development

Exertier, C, Antonelli, L, Liuzzi, A, Ruffa, M, Brufani, V, Colotti, G, Fiorillo, A, Ilari, A.Show

Acs Omega ? ? ? (2026)

DOI: 10.1021/acsomega.6c05158

Primary Citation of related structures

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