ISDA: 28OO

Deposition Date 2026-02-11

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

28OO

Keywords:

RNA BINDING PROTEIN

Title:

Cryo-EM structure of the RESC1-RESC2 complex bound to KREH2

Biological Source:

Source Organism(s):

Trypanosoma brucei brucei (Taxon ID: 5702)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RESC1/2 CYTH-like domain-cont
Gene (Uniprot):Tb07.22O10.680
Chain IDs:A
Chain Length:475
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57XL7

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RESC1/2 CYTH-like domain-cont
Gene (Uniprot):28H13.250
Chain IDs:B
Chain Length:461
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q586X1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RNA editing associated helica
Gene (Uniprot):REH2
Chain IDs:C
Chain Length:20
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q581T1 EC:3.6.4.13

Ligand Molecules

Primary Citation

The RNA helicase KREH2 directly binds the RESC1-RESC2 complex in trypanosomatid mitochondrial RNA editing.

Yelmar, R, Dolce, L.G, Tengo, L, Gabiatti, B.P, Corwin, J, O'Hara, L, Goode, C, Sharma, S.K, Rodshagen, T, Goodall, Z, Cruz-Reyes, J, McDermott, S.M, Kowalinski, E.Show

Biorxiv ? ? ? (2026)

PMID: 42926428 DOI: 10.64898/2026.10.02.754006

Primary Citation of related structures

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