ISDA: 28LP

Deposition Date 2026-02-05

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

28LP

Keywords:

PROTEIN FIBRIL

Title:

Tau filament with delG389_I392 mutation

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.30 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform Tau-C of Microtubule-
Gene (Uniprot):MAPT
Chain IDs:A, B, C, D, E
Chain Length:406
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:P10636 Pfam ID:PF00418

Ligand Molecules

Primary Citation

The Pick fold in tau filaments from human MAPT mutants.

Qi, C, Lovestam, S, Shi, J, Murzin, A.G, Peak-Chew, S, Warner, T.T, Seelaar, H, Cullinane, P.W, Jaunmuktane, Z, van Swieten, J.C, Scheres, S.H.W, Goedert, M.Show

Acta Neuropathol 152 ? ? (2026)

PMID: 42420562 DOI: 10.1007/s00401-026-03049-8

Primary Citation of related structures

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