ISDA: 27XK

Deposition Date 2026-06-16

Release Date 2026-07-01

Last Version Date 2026-07-01

Entry Detail

PDB ID:

27XK

Keywords:

MEMBRANE PROTEIN

Title:

A cryo-EM structure of GLP1-Y11-GLP1R-Gs complex

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)
Rattus norvegicus (Taxon ID: 10116)
Lama glama (Taxon ID: 9844)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.64 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A
Chain Length:361
Number of Molecules:1
Biological Source:Bos taurus

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:B
Chain Length:371
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:P54311 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1(7-36)
Gene (Uniprot):GCG
Mutagens:Author stated: The reported mutation T102Y corresponds to position 11 in our peptide numbering system, based on GLP1(7-36) (residues 98-127 of P01275, renumbered as 1-30)
Chain IDs:C
Chain Length:31
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01275 Pfam ID:PF00123

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody-35
Chain IDs:E (auth: N)
Chain Length:140
Number of Molecules:1
Biological Source:Lama glama

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Chain IDs:F (auth: R)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43220 Pfam ID:PF02793, PF00002

Ligand Molecules

Primary Citation

N-terminally modified GLP1R agonists drive G protein bias via extracellular loop 3 displacement

Zhao, L, Yuan, Q.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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