ISDA: 27EV

Deposition Date 2026-05-28

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

27EV

Keywords:

IMMUNE SYSTEM

Title:

Human Leucocyte Antigen HLA-A2 with bound BHA(543-551) peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Influenza A virus (Taxon ID: 11320)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.86 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Gene (Uniprot):HLA-A
Chain IDs:A
Chain Length:278
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8WLS4

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:B
Chain Length:99
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61769

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:BHA(543-551) peptide
Chain IDs:C
Chain Length:9
Number of Molecules:1
Biological Source:Influenza A virus

Ligand Molecules

Primary Citation

TCR alpha beta repertoire plasticity defines universal CD8+ T cell responses directed at influenza-specific HLA-A*02:01-PB1413-421 epitope.

Koutsakos, M, Crawford, J.C, Grzelak, L, Rizzetto, S, Nguyen, A.T, Chaurasia, P, Petersen, J, Rowntree, L.C, Allen, E.K, Tong, S.Y.C, Cheng, A.C, Kotsimbos, T.C, Luciani, F, Rossjohn, J, Gras, S, Thomas, P.G, Nguyen, T.H.O, Kedzierska, K.Show

J Immunol. 215 ? ? (2026)

PMID: 42886732 DOI: 10.1093/jimmun/vkag270

Primary Citation of related structures

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