ISDA: 24TI

Deposition Date 2026-03-19

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

24TI

Keywords:

MEMBRANE PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of the PCO371-bound GHRHR-Gs complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.88 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAS
Chain IDs:B (auth: A)
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63092 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:C (auth: B)
Chain Length:400
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:P54311 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody35
Chain IDs:E (auth: N)
Chain Length:126
Number of Molecules:1
Biological Source:synthetic construct

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Growth hormone-releasing horm
Gene (Uniprot):GHRHR
Chain IDs:A (auth: R)
Chain Length:556
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q02643 Pfam ID:PF02793, PF00002

Ligand Molecules