ISDA: 24TB

Deposition Date 2026-03-19

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

24TB

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of the ligand-free (Apo) GHRHR-Gs complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAS
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63092 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:B
Chain Length:400
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:P54311 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Growth hormone-releasing horm
Gene (Uniprot):GHRHR
Chain IDs:D (auth: R)
Chain Length:556
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q02643 Pfam ID:PF02793, PF00002

Ligand Molecules

Primary Citation

Structural adaptation associated with signaling preference at the human GHRHR.

Wang, M.W, Hang, K, Qiu, Y, Chen, X, Chen, Y, Huang, S, Cong, Z, Zhou, Q.Show

Protein Cell ? ? ? (2026)

PMID: 41849435 DOI: 10.1093/procel/pwag016

Primary Citation of related structures

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