ISDA: 24SS

Deposition Date 2026-03-19

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

24SS

Keywords:

SIGNALING PROTEIN

Title:

Human KRAS WT (GDP-bound) in complex with macrocyclic peptide inhibitor AUBE00

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.56 Å

R-Value Free:

0.19

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

I 4 2 2

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Chain IDs:A, B, C
Chain Length:179
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:AUBE00
Chain IDs:D (auth: I), E (auth: J), F (auth: K)
Chain Length:12
Number of Molecules:3
Biological Source:synthetic construct

Ligand Molecules