24SQ image
Deposition Date 2026-03-19
Release Date 2026-09-16
Last Version Date 2026-09-16
Entry Detail
PDB ID:
24SQ
Keywords:
SIGNALING PROTEIN/INHIBITOR
Title:
Human HRAS WT (GDP-bound) in complex with macrocyclic peptide inhibitor AP6296
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.08 Å
R-Value Free:
0.20
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
C 1 2 1
24SQ validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:GTPase HRas, N-terminally pro
Chain IDs:A, B
Chain Length:171
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:AP6296
Chain IDs:C (auth: I), D (auth: J)
Chain Length:12
Number of Molecules:2
Biological Source:synthetic construct
Ligand Molecules
EDO
GDP
MG
Primary Citation
Exploiting Bridged Conformations for Precise Molecular Recognition in the Design of KRAS-Selective, Orally Available Macrocyclic Peptides
J.Am.Chem.Soc. ? ? ? (2026)
DOI: 10.1021/jacs.6c14212
Primary Citation of related structures
24SQ
Feedback Form
Name
Email
Institute
Feedback