ISDA: 24KM

Deposition Date 2026-03-06

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

24KM

Keywords:

TRANSCRIPTION

Title:

Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with Nimesulide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.86 Å

R-Value Free:

0.25

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain-containing protei
Gene (Uniprot):BRD4
Chain IDs:A
Chain Length:128
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O60885 Pfam ID:PF00439

Ligand Molecules

NIM

Primary Citation

BET Bromodomain Targeting by NSAIDs: Structural, Biophysical, and Computational Insights.

Sridhar, A, Kandhasami, N, Mathur, S, Krishnappa, G, Thiyagarajan, S, Padmanabhan, B.Show

Proteins ? ? ? (2026)

PMID: 42458221 DOI: 10.1002/prot.70154

Primary Citation of related structures

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