ISDA: 23SO

Deposition Date 2026-02-16

Release Date 2026-07-01

Last Version Date 2026-07-01

Entry Detail

PDB ID:

23SO

Keywords:

MEMBRANE PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of the cebranopadol-mu opioid receptor-Gi complex

Biological Source:

Source Organism(s):

Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.95 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A (auth: B)
Chain Length:345
Number of Molecules:1
Biological Source:Rattus norvegicus

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:B (auth: C)
Chain Length:68
Number of Molecules:1
Biological Source:Bos taurus

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:G (auth: E)
Chain Length:247
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:C (auth: F), F (auth: A)
Chain Length:354
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Mu-type opioid receptor
Chain IDs:D (auth: M), E (auth: R)
Chain Length:400
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules