ISDA: 22PD

Deposition Date 2026-01-19

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

22PD

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Cryo EM structure of SARS-COV-2 (BA.4) RBD in complex with THZ937 Fab (local refine)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Severe acute respiratory syndrome coronavirus (Taxon ID: 2901879)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.95 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:THZ937 fab heavy chain
Chain IDs:A
Chain Length:128
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:THZ937 fab light chain
Chain IDs:B
Chain Length:112
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:SARS-CoV-2 BA.4 spike RBD
Chain IDs:C
Chain Length:200
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus

Ligand Molecules

NAG

Primary Citation

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection.

Zhang, Q, Chen, P, Guo, F, Zhou, R, Guo, R, Ge, X, Yang, Q, Xie, X, Xia, W, Fan, J, Yang, Z, Xu, Y, Huang, H, Li, J, Wang, H, Liao, H, Shi, X, Liu, N, Chen, Y, Chen, Z, Ma, J, Wang, X, Zhang, T, Zhang, L.Show

Immunity ? ? ? (2026)

PMID: 42705227 DOI: 10.1016/j.immuni.2026.08.009

Primary Citation of related structures

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