ISDA: 22NC

Deposition Date 2026-01-16

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

22NC

Keywords:

PROTEIN FIBRIL

Title:

Cryo-EM structure of Orb2 amyloid from 30-day-old Drosophila (4Hc)

Biological Source:

Source Organism(s):

Drosophila melanogaster (Taxon ID: 7227)

Expression System(s):

Drosophila melanogaster

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.78 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translational regulator orb2
Gene (Uniprot):orb2
Chain IDs:A (auth: K), B (auth: D), C (auth: L), D (auth: V), E (auth: T), F (auth: S), G (auth: U), H (auth: W), I (auth: J), J (auth: X), K (auth: H), L (auth: G), M (auth: I), N (auth: B), O (auth: A), P (auth: C), Q (auth: E), R (auth: P), S (auth: F), T (auth: N), U (auth: M), V (auth: O), W (auth: Q), X (auth: b), Y (auth: R), Z, AA (auth: Y), BA (auth: a), CA (auth: c), DA (auth: d)
Chain Length:31
Number of Molecules:30
Biological Source:Drosophila melanogaster

UniProt ID:Q9VSR3

Ligand Molecules

Primary Citation

Age-dependent structural evolution of a functional amyloid contributes to memory impairment in Drosophila.

Ou, S, Guillen-Poza, P.A, Ng, K.K, Xu, L, Cheng, B.Y, Yi, Y, Ho, L.Y, Franco-Fernandez, A, Khaki, P.S.S, Mukhi, M, Cheung, K.C, Sharma, R, Oroz, J, Hirano, Y, Hervas, R.Show

Cell ? ? ? (2026)

PMID: 42962658 DOI: 10.1016/j.cell.2026.10.009

Primary Citation of related structures

Feedback Form