22JX image
Deposition Date 2026-01-14
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
22JX
Keywords:
MEMBRANE PROTEIN/IMMUNE SYSTEM
Title:
Cryo-EM structure of the mGlu5-beta-arrestin 1 complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.70 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
22JX validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Metabotropic glutamate recept
Gene (Uniprot):GRM5
Chain IDs:A, B
Chain Length:892
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P41594 Pfam ID:PF01094, PF07562, PF00003
Polymer Type:polypeptide(L)
Molecule:beta-arrestin 1
Mutagens:C59A, C125S,C140I,C150V,R169E,C242V,C251V,C269S
Chain IDs:C, D, F, H
Chain Length:522
Number of Molecules:4
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:scFv30
Chain IDs:E, G
Chain Length:111
Number of Molecules:2
Biological Source:Mus musculus
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP A SER modified residue
TPO A THR modified residue
Ligand Molecules
GLU
NAG
Primary Citation
Subtype-dependent arrestin engagement of the metabotropic glutamate receptors
To be published ? ? ? (?)
Primary Citation of related structures
22JX
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