ISDA: 22ES

Deposition Date 2026-01-08

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

22ES

Keywords:

SIGNALING PROTEIN/IMMUNE SYSTEM

Title:

Gi bound kappa-opioid receptor in complex with difelikefalin

Biological Source:

Source Organism(s):

Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.43 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(D)
Molecule:DPN-DPN-DLE-DLY-A1L9X
Chain IDs:F (auth: A)
Chain Length:5
Number of Molecules:1
Biological Source:synthetic construct

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:A (auth: B)
Chain Length:354
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:P54311 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:B (auth: C)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:D
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:E
Chain Length:266
Number of Molecules:1
Biological Source:synthetic construct

UniProt ID:22ES

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Kappa-type opioid receptor
Gene (Uniprot):OPRK1
Chain IDs:C (auth: R)
Chain Length:397
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P41145 Pfam ID:PF00001

Ligand Molecules

CLR

Primary Citation

Gi bound kappa-opioid receptor in complex with difelikefalin

Zhang, H, Wang, R, Shi, P, He, X, Zhu, Q, Xu, Y, Yuan, Q, Hu, W, Wu, K, Zheng, Y, Zhou, L, Liang, J, Lv, P, Xu, Z, Zhuang, Y, Xu, H, Wang, Y, Tian, C.Show

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