21ZX image
Deposition Date 2026-01-05
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
21ZX
Keywords:
PROTEIN BINDING
Title:
Crystal structure of Gephyrin E domain with PX-RICS peptide
Biological Source:
Source Organism(s):
Rattus norvegicus (Taxon ID: 10116)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.20 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 1 21 1
21ZX validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 5 of Gephyrin
Gene (Uniprot):Gphn
Chain IDs:A, B, C, D
Chain Length:425
Number of Molecules:4
Biological Source:Rattus norvegicus
UniProt ID:Q03555 Pfam ID:PF03453, PF00994, PF03454 EC:2.7.7.75,2.10.1.1
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Rho GTPase-activating protein
Gene (Uniprot):ARHGAP32
Chain IDs:E (auth: F), F (auth: G)
Chain Length:48
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:A7KAX9
Ligand Molecules
ACT
GOL
Primary Citation
The ARHGAP32 isoform PX-RICS is specifically targeted to inhibitory synapses by binding to gephyrin
Proc.Natl.Acad.Sci.USA ? ? ? (2026)
DOI: 10.1073/pnas.2601488123
Primary Citation of related structures
21ZX
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